Partnership academic - METATOUL

Microbiology & biotechnology

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LABCOM bioplantproduct: aims at identifying new microbial species/associations that optimize the action of the plant microbiota.

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METACLOUD Project aims at unravelling the biological activities of clouds microorganism in addition to chemical reactions by multi-omics approaches.
In this framework, the MetaToul-FluxoMet team will focus it’s activities developing 13C-Metametabolomics to evaluate the biological activities of natural clouds consortium in presence of 13C Formaldehydes and thus provides biological dataset for clouds activities modelling

ciel

metacloud_impactor

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MICROMETABO Project aims at studying the influence of metabolic dialogue within the gut microbiota on host gut metabolism during early development. In this context, 3 sites of MetaToul will develop innovating appraoches (MS imaging, solid medium analysis, multi-omics analysis, network modeling) to understand the symbiotic interaction between drosophile larvae and its microbiota.

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4562

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The BioImpulse project aims to create a new adhesive resin free of substances of very high concern (SVHC). By developing a biosourced molecule of interest, this project will open up new applications for biotechnologies in the materials sector.

bioimpulse

357

645

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MetaPath, a project designed to boost the competitiveness of French companies by shedding light on the functioning of microbial ecosystems used in the agri-food industry, with the aim of designing products that are more natural, healthy, tasty and eco-responsible.

consortia

levain

matrices_fromagère

Human health & toxicology

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GOLIATH Horizon 2020 European project aims at studying metabolic disrupting compounds which can cause adverse health effects (diabetes, obesity). In that context MetExplore team develops computational solutions to integrate metabolomics and trasncriptomics data in metabolic networks.

GOLIATH_2

GOLIATH_1

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MetClassNet projects aims at developping computantional solution to integrate both metabolomics experimental networks (molecular networks, correlation networks) and biochemical networks (genome scale metabolomics networks). The aim is to fill the gap in metabolic networks and enhance metabolite annotation.

METCLASSNET_1

METCLASSNET_2

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Lactate fluxes: The aim of the project is to study the role of brown and beige adipose tissues in maintaining energy and redox homeostasis via inter-organ metabolic dialogues and how their decline during aging contributes to the loss of the metabolic flexibility of the organism. Because of its key role in redox homeostasis, lactate metabolism is particularly investigated, using in vivo 13C-lactate isotopic tracing experiments in mice exhibiting activated or inactivated brown and beige adipose tissues.

LACTACTE_FLUXES_1

LACTACTE_FLUXES_2

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Neuronal metabolism: This project focused on brain metabolism in mice by investigating the effect of altering the activity of an enzyme that regulates glycolysis in neurons on the fate of glucose in the brain. This involved isotopic tracing experiments using 13C-labelled glucose, followed by high-resolution mass spectrometry experiments to measure the metabolic fate of glucose by neurons.

NEURONAL_METABOLISM_1

Mouse

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OPTISTEM: This project is part of the Acceleration Strategy « Biotherapies and Bioproduction of Innovative Therapies ». The aim is to optimise the production of mesenchymal stromal cells, derived from adipose tissue, by identifying their specific metabolic needs during the various stages of production in order to facilitate their therapeutic applications. »

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OPTISTEM

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ADIPOTRYP Project aims at studying in BSF trypanosomes (i) the physiological role of glycerol (as well as phospholipids and fatty acids) in metabolism and development, (ii) the gluconeogenic processes required in glucose-free conditions, which are unconventional in PCF, and (iii) the trypanosome‐adipocyte metabolic interactions. In thi context, the MetaToul-FluxoMet team will analyse by HRMS a NMR the metabolism of the parasites over different conditions and using 13C isoptopic profiling.

ADIPOTRYP

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ADIPOTRYP_3

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MILI project: implication of microbiota lipids in irritable bowel syndrome

Intestinal microbiome, bacteria colonizing small intestine

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EFFICACE project: Genetic control of long-career layer production by combining multi-phenotypes and multi-genomic approaches such as QTL, cis-eQTL and regulatory element detection

EFFICACE

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ANTETAB project: Study of the potential for alveolar regeneration after exposure to passive smoking in utero and implication of lipid signalling

ANTETAB

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OCTOPUS: Full Caracterisation of skin sample in the context of agging

Skin Aging Anatomy

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EMERGINGMYCO: Emerging mycotoxins: a new risk for Human and animals according to their metabolism and to metabolomics? AXIOM is leading 2 workpackages: (i) the development and application of an in-vitro production method of standards of xenobiotics metabolites to enable their identification by untargeted mass spectrometry, and (ii) application of untargeted HRMS based metabolomics on plasma and liver of pig to understand biological effects of emerging mycotoxins

EMERGINGMYCO

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SCREENPEST: development and implementation of a new large-scale screening approach for extended characterization of human exposure to pesticides. AXIOM is managing this project, in which 3 laboratories develop and apply 3 suspect screening HRMS based methods (GC-MS, HILIC-MS, RPLC-MS) from a same unique extract to characterize the chemical internal human exposome.

SCREENPEST

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MIXMEAT: quantification of heterocyclic aromatic amines in new hybrid food: extraction and absolute quantification by LC-MS of the genotoxic heterocyclic aromatic amine in food product enriched in proteins used as alternative of meat.

MIXMEAT

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INSPIRE project: collaborative project hosted at INSERM RESTORE Toulouse with Metatoul on aging. NMR-based metabolomic and lipidomic study of human cohort (1000 subjects during 5-10 years) to identify predictive biomarkers of frailty. Statistic tools will be developed to integrate metabolomic, lipidomic and clinical data for a better prediction of frailty.

INSPIRE

INSPIRE_2

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BEEP-FAME project: collaborative project between Tel Aviv University (Israël) and INRAE Toxalim Toulouse on assessment of effects of major endocrine disruptors on female fertility. This work is based on the characterization of biomarker metabolites or metabolic shifts that occur in follicular fluid samples using NMR-based metabolomics

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Plant agronomy

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WITT project: collaborative project hosted at INRAE Clermont by Cyrille Santenac on wheat resistance against septoriose.

WITT_1

WITT_2

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Chemomaps project try to tackle the chemodiversity of living organism, its deep architecture and evolution.

CHEMOMAPS